Prenatal aneuploidy screening using cell free DNA
نویسندگان
چکیده
منابع مشابه
Prenatal aneuploidy screening using cell-free DNA.
REFERENCES 1. Hammers AL, Sanchez-Ramos L, Kaunitz AM. Antenatal exposure to indomethacin increases the risk of severe intraventricular hemorrhage, necrotizing enterocolitis, and periventricular leukomalacia: a systematic review with metaanalysis. Am J Obstet Gynecol 2015;212:505.e1-13. 2. Ment LR, Ådén U, Lin A, et al. Gene-environment interactions in severe intraventricular hemorrhage of pret...
متن کاملDNA sequencing versus standard prenatal aneuploidy screening.
BACKGROUND In high-risk pregnant women, noninvasive prenatal testing with the use of massively parallel sequencing of maternal plasma cell-free DNA (cfDNA testing) accurately detects fetal autosomal aneuploidy. Its performance in low-risk women is unclear. METHODS At 21 centers in the United States, we collected blood samples from women with singleton pregnancies who were undergoing standard ...
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Background: The aim of this study was to compare noninvasive prenatal testing (NIPT) of cell‐free DNA in maternal blood and amniocentesis in the diagnosis of aneuploidy. This study was designed to evaluate sensitivity, specificity, accuracy, positive predictive value and negative predictive value of NIPT for detection of aneuploidies compared gold standard test of amniocentesis. Materials and m...
متن کاملCopy-number variation and false positive prenatal aneuploidy screening results.
Investigations of noninvasive prenatal screening for aneuploidy by analysis of circulating cell-free DNA (cfDNA) have shown high sensitivity and specificity in both high-risk and low-risk cohorts. However, the overall low incidence of aneuploidy limits the positive predictive value of these tests. Currently, the causes of false positive results are poorly understood. We investigated four pregna...
متن کاملPrenatal Screening for and Diagnosis of Aneuploidy in Twin Pregnancies
Objective: To provide a Canadian consensus document with recommendations on prenatal screening for and diagnosis of fetal aneuploidy (e .g ., Down syndrome and trisomy 18) in twin pregnancies . Options: The process of prenatal screening and diagnosis in twin pregnancies is complex . This document reviews the options available to pregnant women and the challenges specific to screening and diagno...
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ژورنال
عنوان ژورنال: American Journal of Obstetrics and Gynecology
سال: 2015
ISSN: 0002-9378
DOI: 10.1016/j.ajog.2015.06.025